岐阜大学 · 医学部附属病院

研究キーワードosteoblast signaling・osteoprotegerin synthesis・MAP kinase pathways・EGF-induced cell migration・HSP90 inhibition・BMP-4 signaling・interleukin-6 production・prostaglandin signaling

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• Tramadol enhances PGF2α-stimulated osteoprotegerin synthesis in osteoblasts.
• Enhancement by HSP90 inhibitor of PGD2-stimulated HSP27 induction in osteoblasts: Suppression of SAPK/JNK and p38 MAP kinase.
• Incretins Enhance PGF2α-Induced Synthesis of IL-6 and Osteoprotegerin in Osteoblasts.
• HSP90 inhibitors strengthen extracellular ATP-stimulated synthesis of interleukin-6 in osteoblasts: Amplification of p38 MAP kinase.

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