順天堂大学 · 医学研究科/医学部 · 特任助教

研究キーワードbreast cancer glycosylation・MUC1 localization・MUC-21 immune resistance・NK-cell evasion・tumor metastasis glycoprofiles・macrophage galactose-type lectin・antigen-presenting cells in skin disease・cancer glycobiology

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• Horimoto Y, Hlaing MT, Saeki H, Denda-Nagai K, Ishii-Schrade K, Fujihira H, Abe M, Noji M, Shichino S, Saito M, Irimura T. Glycosylation profiles of breast cancer cells may represent clonal variations of multiple organ metastases. Clin Exp Metastasis 2024;41(3)267-270.2024
• Lee DH, Ahn H, Sim HI, Choi E, Choi S, Jo Y, Yun B, Song HK, Oh SJ, Denda-Nagai K, Park CS, Irimura T, Park Y, Jin HS. A CRISPR activation screen identifies MUC-21 as critical for resistance to NK and T cell-mediated cytotoxicity. J Exp Clin Cancer Res 2023 42(1):272.2023
• Semba R, Horimoto Y, Sakata-Matsuzawa M, Ishizuka Y, Denda-Nagai K, Fujihira H, Noji M, Onagi H, Ichida M, Miura H, Watanabe J, Saito M, Saito T, Arakawa A, Irimura T. Possible correlation of apical localization of MUC1 glycoprotein with luminal A-like status of breast cancer. Sci Rep 2023;13(1):5281.2023
• Manome-Zenke Y, Denda-Nagai K‡, Murakami R, Noji M, Tsuneda N, Ishii-Schrade KB, Kanomata N, Arai S, Irimura T, Ikeda S. Possible Involvement of Antigen-Presenting Cells Expressing the Macrophage Galactose-Type C-Type Lectin in Inflammatory Skin Diseases. J Invest Dermatol 2023;143(9):1834-1838.e10. (‡: corresponding author)2023

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