鹿児島大学 · 医歯学総合研究科

研究キーワードgroup 2 innate lymphoid cells・asthma・eosinophilic airway inflammation・long-acting muscarinic antagonists・cold temperature exposure・airway inflammation・cold-induced airway responses・pulmonary metastasis

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• Dotake Y, Matsuyama T, Machida K, Matsuyama H, Takagi K, Mizuno K, Kan-O K, Kuwaki T, Inoue H, Tanaka K . Cold temperature enhances innate eosinophilic airway inflammation via transient2025 · 担当区分： 筆頭著者 記述言語： 英語 DOI： 10.3389/fimmu.2025.1655919
• Matsuyama T., Tanaka K., Kitazono I., Kondo K., Satomura M., Matsuyama H., Sasaki H., Tanimoto A., Taniguchi N., Inoue H. . Pulmonary metastasis of chondrosarcoma diagnosed by transbronchial l2025 · 担当区分： 筆頭著者 記述言語： 英語 掲載種別： 研究論文（学術雑誌） 出版者・発行元： Respiratory Investigation A 49-year-old woman presented with abdominal distention and right leg numbness. Bone biopsy from a huge tumor in her pelvis revealed chondrosarcoma, and proton beam therapy was performed. Although there were no abnormalities at 6 months, dry cough, dyspnea and fever with elevated inflammation appeared at 9 months. Computed tomography showed multiple consolidations in both lungs, different from typical images of nodular shadows with calcification in pulmonary metastases of chondrosarcoma. We first suspected infection or organizing pneumonia, but biopsy revealed chondrosarcoma metastases with severely infiltrated inflammatory cells. Imaging patterns we experienced may reflect inflammatory pathogenesis due to rapid cancer progression. DOI： 10.1016/j.resinv.2025.07.017 Scopus PubMed
• Matsuyama T., Salter B.M., Emami Fard N., Machida K., Sehmi R. . TNF Superfamily and ILC2 Activation in Asthma . Biomolecules14 ( 3 ) 2024年2024 · 担当区分： 筆頭著者 記述言語： 英語 掲載種別： 研究論文（学術雑誌） 出版者・発行元： Biomolecules Eosinophilic asthma is the most prevalent and well-defined phenotype of asthma. Despite a majority of patients responding to corticosteroid therapy and T2 biologics, there remains a subset that have recurrent asthma exacerbations, highlighting a need for additional therapies to fully ameliorate airway eosinophilia. Group 2 innate lymphoid cells (ILC2) are considered key players in the pathogenesis of eosinophilic asthma through the production of copious amounts of type 2 cytokines, namely IL-5 and IL-13. ILC2 numbers are increased in the airways of asthmatics and with the greatest numbers of activated ILC2 detected in sputa from severe prednisone-dependent asthma with uncontrolled eosinophilia. Although epithelial-derived cytokines are important mediators of ILC2 activation, emerging evidence suggests that additional pathways stimulate ILC2 function. The tumor necrosis factor super family (TNFSF) and its receptors (TNFRSF) promote ILC2 activity. In this review, we discuss evidence supporting a relationship between ILC2 and TNFSF/TNFRSF axis in eosinophilic asthma and the role of this relationship in severe asthma with airway autoimmune responses. DOI： 10.3390/biom14030294 Scopus PubMed
• Matsuyama T., Kubota K., Tsuruzono K., Uchida H., Hamasaki T., Mizuno K., Inoue H. . Primary mediastinal choriocarcinoma requiring differentiation from non-small cell lung cancer: An autopsy c2024 · 担当区分： 筆頭著者 記述言語： 英語 掲載種別： 研究論文（学術雑誌） 出版者・発行元： Respiratory Medicine Case Reports A 65-year-old man with dyspnea and hemoptysis presented with a right upper lobe mass associated with enlarged mediastinal lymph nodes and bilateral pulmonary nodules on chest computed tomography (CT), suspected lung cancer. Bronchial and CT-guided biopsies revealed poorly differentiated carcinoma. His condition deteriorated rapidly before a definitive diagnosis could be made. Autopsy revealed primary mediastinal choriocarcinoma. Primary mediastinal choriocarcinomas are rare, difficult to diagnose early and have a poor prognosis. In patients with a tumor expanding across the lung and mediastinum and exhibiting pathologic findings of a pooly differentiated carcinoma, we should consider choriocarcinoma, evaluating the serum β-human chorionic gonadotropin levels. DOI： 10.1016/j.rmcr.2024.102037 Scopus PubMed

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