鹿児島大学 · 診療センター

研究キーワードperiodontal ligament cells・BMP-9 osteogenesis・PI3K/Akt signaling・SDF-1 production・alveolar bone regeneration・Porphyromonas gingivalis・SARS-CoV-2 entry genes

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• Sena K., Furue K., Setoguchi F., Noguchi K. . Altered expression of SARS-CoV-2 entry and processing genes by Porphyromonas gingivalis-derived lipopolysaccharide, inflammatory cytokines and pro2021 · 記述言語： 日本語 出版者・発行元： Archives of Oral Biology Objective: The aim of this in vitro study was to investigate the expression of SARS-CoV-2 entry and processing genes in human gingival fibroblasts (HGnF) following treatment with Porphyromonas gingivalis-derived lipopolysaccharide (PgLPS) or inflammatory cytokines/mediators. Design: We assessed the expression of SARS-CoV-2 entry and processing genes; angiotensin-converting enzyme 2 (ACE2), cellular serine proteases transmembrane serine protease 2 (TMPRSS2), Furin, and basigin (BSG) in HGnF by real-time PCR. To further asses the contribution of PgLPS and inflammatory cytokines/mediators to proliferation and SARS-CoV-2 entry and processing gene expression, HGnF were treated with PgLPS, IL1β, TNFα, and PGE2. Results: The expression for ACE2 in HGnF was significantly elevated after PgLPS or IL1β, TNFα, PGE2 treatment. The expression of TMPRSS2 was increased by PgLPS, IL1β, or PGE2 while BSG was elevated by PgLPS and IL1β. The expression of BSG and FURIN decreased after TNFα treatment. Conclusion: SARS-CoV-2 entry and processing genes are expressed in human gingival fibroblasts and their expressions are altered by PgLPS, IL1β, TNFα and PGE2 treatment. DOI： 10.1016/j.archoralbio.2021.105201 Scopus PubMed
• Furue K, Sena K, Sakoda K, Nakamura T, Noguchi K2017 · 担当区分： 筆頭著者 記述言語： 英語 掲載種別： 研究論文（学術雑誌）
• 3. Nakamura T, Shirakata Y, Shinohara Y, Miron RJ, Furue K, Noguchi K.2017 · 記述言語： 英語 掲載種別： 研究論文（学術雑誌）
• 2. Fuchigami S, Nakamura T, Furue K, Sena K, Shinohara Y, Noguchi K.2016 · 記述言語： 英語 掲載種別： 研究論文（学術雑誌）

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