Arimura E., Maruguti Y., Nakao Y., Ushikai M., Yotsueda K., Kajiya S., Nishio Y., Horiuchi M. . Nutritional Risk Factors in Albuminuria and Retinopathy in Patients Newly Diagnosed With Type 22025 · 記述言語： 英語 出版者・発行元： In Vivo Background/Aim: Although nutritional risk factors for developing complications in type 2 diabetes mellitus (T2DM) have been examined, the effect of protein intake on nephropathy is debated, and there is little research on retinopathy. This cross-sectional case-series study aimed to examine the risk factors, including nutritional status, for complications in patients newly diagnosed with T2DM. Patients and Methods: Fifty-four patients were recruited, based on the results of examinations of blood glucose and/or glycated hemoglobin level for T2DM. To evaluate nutritional status, blood and urine examinations were performed and the Food Frequency Questionnaire was administered. Two-way analysis of variance, Fisher’s exact test and logistic regression analyses were performed. Results: The patients were categorized into four groups: 24 without albuminuria and without retinopathy, four without albuminuria with retinopathy, 21 with albuminuria without retinopathy, and five with albuminuria with retinopathy. Logistic analysis of albuminuria revealed that estimated sodium intake was significantly independent as the explanatory factors of age, sex, and body mass index. Patients with retinopathy had significantly higher blood urea nitrogen, and significantly lower plasma total protein levels than patients without retinopathy, suggesting that retinopathy is related to a higher catabolic state. Through a questionnaire on food intake, patients with retinopathy had a significantly lower intake of fat and monounsaturated fatty acids and a significantly higher intake of iodine based on intake of seaweed, corrected for energy intake, than patients without retinopathy. Conclusion: The present study may lead to planning a large cohort study for examining nutritional risk factors related to complications in patients newly diagnosed with T2DM in Japan. DOI： 10.21873/invivo.13722 Scopus PubMed
Jin’o Y., Ushikai M., Komaki Y., Masuda K., Horiuchi M. . Involvement of community pharmacy pharmacists in fecal immunochemical test screening without government support in Japan . Plo2023 · 記述言語： 日本語 出版者・発行元： Plos One Colorectal cancer (CRC) is the third most common malignancy and second leading cause of death worldwide. However, the screening rate, which is a typical preventive measure, remains low. A community pharmacy pharmacist (CPP)-mediated procedure was used to increase the CRC screening rate. A total of 37 community pharmacies in Kagoshima, a core city in Japan, participated in this study. The results were statistically compared with the results of two procedures in Kagoshima City: hospital/ clinic institution-mediated and health examination institution-mediated procedures. The cost was set at 1,100 JPY to perform a fecal immunochemical test, considering the costs as the self-payment of the other two procedures. In March 2023, 2,611 kits were distributed, and 273 tests were conducted under the research conditions. A significantly higher percentage of people in their 40s were tested using CPP-mediated procedures (35.2% vs. 14.3% in the hospital/clinic, and 21.8% in the health examination institution, respectively, p<0.01). The percentage of participants who underwent a detailed examination at CPP facilities was significantly lower than in the other two groups (46.7% vs. 87.3% in the hospital/clinic, and 83.0% in the health examination institution, p<0.05). In the CPP-mediated procedure, the test result turn-around time was approximately one day. Although a 2-day method was used, the implementation rate was 100%. The CPP-mediated procedure did not differ significantly from hospital/clinic or health examination institution procedures in terms of the number of detailed examination findings. In particular, the CPP-mediated procedure may address gaps by increasing the number of young people and people with reduced opportunities who receive CRC screening. The CPP-mediated procedure could be implemented as a new procedure with certain advantages. Moreover, it should be considered that this procedure can be implemented and sustained in society without government support. DOI： 10.1371/journal.pone.0322879 Scopus PubMed
