北里大学 · 大村智記念研究所

研究キーワード天狗の麦飯・微生物創薬・糸状菌・天然物探索

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• The isolation of sclerotinin A as an anti-malarial compound by utilization of a global secondary metabolism regulator, laeA gene.
• Re-discovery of MS-347a as a fungicide candidate through a new drug discovery platform with a multidrug-sensitiveSaccharomyces cerevisiaescreening system and the introduction of a global secondary metabolism regulator,laeAgene
• Discovery of an anti-malarial compound, burnettiene A, with a multidrug-sensitive Saccharomyces cerevisiae screening system based on mitochondrial function inhibitory activity
• Synthesis and biological evaluation of MS-347a derivatives against plant pathogenic fungi based on a strategy of laeA gene introduction

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