横浜薬科大学 · 健康薬学科 · 准教授

研究キーワード●血液凝固系におけるMgイオンの役割の解明・●新規生物活性を有するタンパクの探索とその構造の決定

研究分野血液、腫瘍内科学

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• 1. Chen H, Wei T, Saotome A, Sakaguchi K, Shikamoto Y , Mizuno H, Akita F, Shimizu T, Uehara-Ichiki T, Omura T. Aggregation ability of virus-specific antibodies is correlated with their capacity to neutralize Rice dwarf virus. (2012) JARQ. 46(1): 65-71.2012
• 2. Gopinath SC, Shikamoto Y , Mizuno H, Kumar PK. Snake-venom-derived Factor IX-binding protein specifically blocks the gamma-carboxyglutamic acid-rich-domain-mediated membrane binding of human Factors IX and X. (2007) Biochem. J. 405(2):351-7.2007
• 4. Nakagawa T, Shikamoto Y , Mizuno H, Murase T, Ishii H, Nakabayashi T, Ieko M, Mizukami K, Naitoh S, Takeda M, Tarumi T, Kaneko H. Molecular dynamics calculations of wild type vs. mutant protein C: relationship between binding affinity to endothelial cell protein C receptor and hereditary disease. (2006) J. Biomol. Struct. Dyn. 24(3):203-7.2006
• 3. Gopinath SC, Shikamoto Y , Mizuno H, Kumar PK. A potent anti-coagulant RNA aptamer inhibits blood coagulation by specifically blocking the extrinsic clotting pathway. (2006) Thromb. Haemost. 95(5):767-71.2006

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