琉球大学 · 医学部

研究キーワードMaternal and Child Health・Developmental Epidemiology・Perinatal Epidemiology・Nutritional Epidemiology・Environmental Epidemiology・Vaccine Uptake・Sleep Epidemiology・Child Development

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• Association between Total Fruit Consumption and Risk of Gestational Diabetes Mellitus: The Japan Environment and Children's Study2025 · INTRODUCTION: Whether the consumption of fruits, flavonoid-rich fruits, and 100% fruit juice is associated with the risk of gestational diabetes mellitus (GDM) is unclear. We aimed to examine the association of total fruit, flavonoid-rich fruits, and 100% fruit juice consumption with the risk of GDM. METHODS: A total of 93,759 singleton pregnancies who were enrolled in the Japan Environment and Children's Study remained for the analysis. Total fruit consumption including fruits and 100% fruit juice during the past year in the first trimester was assessed using a validated food frequency questionnaire (FFQ). Odds ratios (ORs) and 95% confidence intervals (CIs) for GDM associated with total fruit, flavonoid-rich fruits, non-flavonoid-rich fruits, and 100% fruit juice consumption were estimated using logistic regression analysis. RESULTS: GDM occurred in 2,096 (2.2%) of the 93,759 pregnant women. Total fruit consumption was inversely associated with the risk of GDM; the multivariable ORs (95% CI) for the highest vs lowest quartiles of total fruit consumption were 0.82 (0.71, 0.95) (p for trend = 0.013). An increase in total fruit consumption by each 100 g/d was inversely associated with the risk of GDM [OR = 0.94 (0.91, 0.98), p for trend = 0.001)]. The multivariable ORs (95% CIs) for the highest versus lowest quartiles of flavonoid-rich fruits consumption was 0.80 (0.70, 0.93) (p for trend = 0.003), whereas that for non-flavonoid-rich fruits consumption was 0.96 (0.83, 1.11) (p for trend = 0.504); 100% fruit juice consumption was inversely associated with the risk of GDM for each 100 g/d increase (OR = 0.91, 95% CI: 0.87, 0.96). CONCLUSION: Total fruit consumption, flavonoid-rich fruits and 100% fruit juice consumption were inversely associated with risk of GDM.
• Association of Nighttime Sleep Duration at 1.5 Years With Height at 3 Years: The Japan Environment and Children's Study2025 · Masanobu Kawai, Sachiko Baba, Kanami Tanigawa, Satoyo Ikehara, Ryo Kawasaki, Hiroyasu Iso
• Risk score for non-vaccination of voluntary vaccines: The Japan Environment and Children's Study.2025 · BACKGROUND: In Japan, as several important vaccines are still categorized as voluntary vaccines that require out-of-pocket payment, the vaccination coverage of voluntary vaccines is lower than that of routine vaccines. Thus, higher voluntary vaccination rates are desired. Herein, we used nationwide birth cohort data to create a voluntary vaccine risk score to identify high-risk individuals who were not vaccinated with voluntary vaccines. METHODS: The data from 74,733; 73,571; and 74,360 infants were analyzed for rotavirus, mumps virus, and influenza virus vaccinations, respectively. The risk score for non-vaccination of voluntary vaccines was created from the regression coefficients of the logistic regression models. RESULTS: The items included for the score resulted from the analysis were the mother's drug allergy history, mother's depression history, mother's educational background, father's educational background, household income, maternal smoking during pregnancy, paternal smoking during pregnancy, fertility treatment, number of siblings, maternal drinking at 1 month of age, maternal age, and maternal nationality. The mother's drug allergy history, mother's depression history, fertility treatment, maternal drinking at 1 month of age, and maternal nationality were factors not previously reported and associated with taking voluntary vaccine. The receiver operating characteristic curve of the risk score for non-vaccination of voluntary vaccines suggested that a score ≥16 predicted non-vaccinated infants for rotavirus, mumps virus, and influenza virus vaccines with 78.6%, 75.0%, and 74.5% sensitivity and 44.2%, 43.2%, and 37.1% specificity, respectively. CONCLUSIONS: We developed a risk score for non-vaccination of voluntary vaccines consisting of 10 domains with high sensitivity but low specificity.
• Associations between antenatal organophosphate pesticide exposure and pregnancy outcomes: The Japan Environment and Children's Study (JECS)2025 · Baba S, Tanigawa K, Nakayama SF, Nishihama Y, Hirata K, Ikehara S, Miyazaki J, Kawasaki R, Iso H.

• 母子の栄養関連尿中バイオマーカーと高血圧、肥満発症リスク：12年追跡研究2024 · 基盤研究(C)
• 子育て期の女性と子どもの健康に影響を与える子育て環境要因を把握する社会疫学研究2020 · 基盤研究(B)
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• 母親及び小児の尿中バイオマーカーと高血圧・糖尿病への進展に関するコホート研究2018 · 基盤研究(B)

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