東北大学 · 薬学部 / 薬学研究科

研究キーワードH2A.Z deposition・YEATS domain・histone H3 recognition・histone sorbylation・HDAC1・chromatin regulation

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• Identification of a derivative of the alkaloid emetine as an inhibitor of the YAP-TEAD interaction and its potential as an anticancer agent.Saaya Sekine, Shohei Takase, Runa Hayase, Kota Noritsugu, Yuki Maemoto, Yasue Ichikawa, Kenji Ogawa, Yasumitsu Kondoh, Hiroyuki Osada, Minoru Yoshida, Akihiro Ito
• Identification of zinc finger transcription factor EGR2 as a novel acetylated proteinKota Noritsugu, Akihiro Ito, Yoichi Nakao, Minoru Yoshida
• Lysine long-chain fatty acylation regulates the TEAD transcription factorKota Noritsugu, Takehiro Suzuki, Kosuke Dodo, Kenji Ohgane, Yasue Ichikawa, Kota Koike, Satoshi Morita, Takashi Umehara, Kenji Ogawa, Mikiko Sodeoka, Naoshi Dohmae, Minoru Yoshida, Akihiro Ito
• Improving reactivity of naphthalimide-based GST probe by imparting TPP cation: Development and application for live cell imagingYuuta Fujikawa, Kenta Terakado, Sayaka Nezu, Kota Noritsugu, Yuki Maemoto, Akihiro Ito, Hideshi Inoue

• TEADのアセチル化、長鎖アシル化修飾間クロストークによる新規活性制御機構の解明則次 恒太

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