東京科学大学 · 医歯学総合研究科 · 特任助教

研究キーワードhematology・acute myeloid leukemia・FLT3-ITD・STAT5 signaling・Pim kinases・clonal hematopoiesis・mutant p53・Waldenstrom macroglobulinemia

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• Ran Zhao, Liang Zhang, Shuxin Dong, Kazuharu Kamachi, Saurabh Kumar Gupta, Hiroki Akiyama, Jalen Nguyen, G Lavender Hackman, Michael Andreeff, Alessia Lodi, Jo Ishizawa. Protocol for isolation of lipid droplets and mitochondria from acute myeloid leukemia cells for lipidomic analysis. STAR Protocol. 2025.12; 6 (4): 104257. ( PubMed , DOI )2025
• Akiyama H, Nishida Y, Chang KH, Bedoy AD, Muftuoglu M, Ma W, Basyal M, Hirschi Z, Honma D, Tsutsumi S, Wang J, Zhang W, Huang X, Rampal RK, Oluwole OO, Bixby DL, Daver NG, Andreeff M. Dual targeting of EZH2 and EZH1 drives exit of leukemia stem cells from quiescence and potentiates chemotherapy in acute myeloid leukemia. Blood cancer journal. 2025.04; 15 (1): 76. ( PubMed , DOI )2025
• Pourebrahim R, Montoya RH, Akiyama H, Ostermann L, Khazaei S, Muftuoglu M, Baran N, Zhao R, Lesluyes T, Liu B, Khoury JD, Gagea M, Van Loo P, Andreeff M. Age-specific induction of mutant p53 drives clonal hematopoiesis and acute myeloid leukemia in adult mice. Cell reports. Medicine. 2024.05; 5 (5): 101558. ( PubMed , DOI )2024
• Akiyama H, Zhao R, Ostermann LB, Li Z, Tcheng M, Yazdani SJ, Moayed A, Pryor ML 2nd, Slngh S, Baran N, Ayoub E, Nishida Y, Mak PY, Ruvolo VR, Carter BZ, Schimmer AD, Andreeff M, Ishizawa J. Correction: Mitochondrial regulation of GPX4 inhibition-mediated ferroptosis in acute myeloid leukemia. Leukemia. 2024.04; 38 (4): 926. ( PubMed , DOI )2024

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