東京科学大学 · 医歯学総合研究科 · 准教授

研究キーワードhematopoietic stem cells・genome engineering・AAV-mediated repair・preleukemic stem cells・oxidative phosphorylation・stem cell metabolism・stress hematopoiesis・mitochondrial ATP production・RUNX1 deficiency・quiescent stem cell culture

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• Fabian P Suchy, Daiki Karigane, Yusuke Nakauchi, Maimi Higuchi, Jinyu Zhang, Katja Pekrun, Ian Hsu, Amy C Fan, Toshinobu Nishimura, Carsten T Charlesworth, Joydeep Bhadury, Toshiya Nishimura, Adam C Wilkinson, Mark A Kay, Ravindra Majeti, Hiromitsu Nakauchi. Genome engineering with Cas9 and AAV repair templates generates frequent concatemeric insertions of viral vectors. Nat Biotechnol. 2025.02; 43 (2): 204-213. ( PubMed , DOI )2025
• Niklas Landberg, Thomas Köhnke, Yang Feng, Yusuke Nakauchi, Amy C Fan, Miles H Linde, Daiki Karigane, Kelly Lim, Rahul Sinha, Luca Malcovati, Daniel Thomas, Ravindra Majeti. IDH1-Mutant Preleukemic Hematopoietic Stem Cells Can Be Eliminated by Inhibition of Oxidative Phosphorylation. Blood Cancer Discovery. 2024.01; OF1-OF18. ( PubMed , DOI )2024
• Amy C Fan, Yusuke Nakauchi, Lawrence Bai, Armon Azizi, Kevin A Nuno, Feifei Zhao, Thomas Köhnke, Daiki Karigane, David Cruz-Hernandez, Andreas Reinisch, Purvesh Khatri, Ravindra Majeti. RUNX1 loss renders hematopoietic and leukemic cells dependent on IL-3 and sensitive to JAK inhibition. Journal of Clinical Investigation. 2023.10; 133 (19): ( PubMed , DOI )2023
• Kohei Shiroshita, Hiroshi Kobayashi, Shintaro Watanuki, Daiki Karigane, Yuriko Sorimachi, Shinpei Tamaki, Miho Haraguchi, Masamichi Yamamoto, Ayako Nakamura-Ishizu, Shinichiro Okamoto, Keisuke Kataoka, Keiyo Takubo. Distinct roles of the preparatory and payoff phases of glycolysis in hematopoietic stem cells. Experimental Hematology. 2023.08; 124 56-67. ( PubMed , DOI )2023

• IL-2/CD25系に着目したCML幹細胞の維持プログラム同定と臨床的意義の検証
• 造血幹細胞におけるセリン・グリシン合成系の機能解析
• 造血幹細胞増幅剤の標的同定と機能解析
• 二つの水酸化シグナルによる造血恒常性の統御機構の解明

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