東京科学大学 · 医歯学総合研究科 · 講師

研究キーワードmuscle regeneration・tendon development・enthesis biology・skeletal muscle stem cells・bone healing

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• Hiroyuki Koike, Miho Sugimura, Rie Ouchi, Yuki Yoshimoto, Ichiro Manabe, Yumiko Oishi. Macrophage Subpopulation Promotes Skeletal Muscle Regeneration Through HGF/MET Signaling-Mediated Skeletal Muscle Stem Cell Proliferation. Aging Cell. 2025.06; 24 (6): e70042. ( PubMed , DOI )2025
• Xinyi Yu, Ryosuke Kawakami, Shinsei Yambe, Yuki Yoshimoto, Takako Sasaki, Shinnosuke Higuchi, Hitomi Watanabe, Haruhiko Akiyama, Shigenori Miura, Kadi Hu, Gen Kondoh, Ramu Sagasaki, Masafumi Inui, Taiji Adachi, Denitsa Docheva, Takeshi Imamura, Chisa Shukunami. Dynamic interactions between cartilaginous and tendinous/ligamentous primordia during musculoskeletal integration. Development. 2025.03; 152 (6): ( PubMed , DOI )2025
• Yambe, S; Yoshimoto, Y; Ikeda, K; Maki, K; Takimoto, A; Tokuyama, A; Higuchi, S; Yu, XY; Uchibe, K; Miura, S; Watanabe, H; Sakuma, T; Yamamoto, T; Tanimoto, K; Kondoh, G; Kasahara, M; Mizoguchi, T; Docheva, D; Adachi, T; Shukunami, C. Sclerostin modulates mineralization degree and stiffness profile in the fibrocartilaginous enthesis for mechanical tissue integrity Frontiers in Cell and Developmental Biology. 2024.06; 12 1360041. ( PubMed , DOI )2024
• Kurosawa, T; Ikemoto-Uezumi, M; Yoshimoto, Y; Minato, K; Kaji, N; Chaen, T; Hase, E; Minamikawa, T; Yasui, T; Horiguchi, K; Iino, S; Hori, M; Uezumi, A. Tissue-specific functions of MSCs are linked to homeostatic muscle maintenance and alter with aging Aging Cell. 2024.11; 23 (11): e14299. ( PubMed , DOI )2024

• iPS細胞を用いた腱・靭帯細胞への分化誘導系の確立
• 老化や損傷および疾患で破綻する腱・靱帯の異所性骨化抑制メカニズムの解明
• 遺伝子改変マウスを用いた歯根形成・維持に関与する分子機構の解明
• ゲノム編集技術を用いた鎖骨頭蓋異形成症モデルマウスの作成と解析

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