滋賀県立大学 · 人間文化学部／生活栄養学科

研究キーワードmaternal nutrition・Wagyu fetuses・amniotic fluid amino acids・fetal muscle development・adipose tissue development・angiogenesis・microRNA expression・energy metabolism

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• Maternal Undernutrition during Pregnancy Alters Amino Acid Metabolism and Gene Expression Associated with Energy Metabolism and Angiogenesis in Fetal Calf Muscle2021 · 記述言語： 英語 掲載種別： 研究論文（学術雑誌） 参加形態： 共同（副担当） DOI： 10.3390/metabo11090582
• Maternal Nutrition During Gestation Alters Histochemical Properties, and mRNA and microRNA Expression in Adipose Tissue of Wagyu Fetuses2021 · 記述言語： 英語 掲載種別： 研究論文（学術雑誌） 出版者・発行元： Frontiers in Endocrinology We hypothesized that maternal low or high nutrition would give unique effects to morphological and molecular dynamics in adipose tissue of fetus of fatty breed Wagyu (Japanese Black) cattle which produce highly marbled beef. This study aimed to determine the effects of maternal energy intake in Wagyu cows, during gestation on fetal adipose tissue development, histochemical properties, and gene and microRNA (miRNA) expression. Cows were allocated to one of two nutritional energy groups: 120% (HIGH) or 60% nutritional requirements of (LOW). Fetuses (n = 6 per treatment) were removed from pregnant cows by cesarean section at fetal age 260 ± 8 days and euthanized. Subcutaneous adipose tissue (SAT), thoracic cavity visceral adipose tissue (TVAT), and perirenal adipose tissue (PAT) were collected for analysis. In histochemical analysis, in SAT and PAT, HIGH fetuses had greater diameter of adipocytes than LOW fetuses (P<0.05). Only in SAT, LOW fetuses had more Leptin (LEP) mRNA and tended to have more Peroxisome Proliferator-Activated Receptor gamma (PPARG) CCAAT-enhancer-binding proteins alpha (CEBPA) and Glucose transporter (GLUT) 4 mRNA(P<0.10). In all SAT, TVAT, and PAT, LOW fetuses had higher levels of the brown adipose tissue (BAT) biomarkers Uncoupling Protein (UCP) 1 and PPARG coactivator (PGC) 1α mRNA than HIGH fetuses (P<0.08). Meanwhile, in the other adipose tissue, LOW fetuses had lower PPARG, CEBPA, and Zinc Finger Protein (ZFP) 423 (in TVAT and PAT), FASN (in TVAT), LEP and GLUT4 mRNA (in PAT; P<0.10). In particular, in TVAT and PAT, LOW fetuses exhibited lower expression of WAT biomarkers (PPARG and ZFP423). Differential expression of various miRNAs related to adipogenesis between the LOW and HIGH fetuses was detected in an adipose tissue-specific manner (P<0.10). Based on adipose tissue-specific effects of maternal nutrition, these findings suggested that poor maternal nutrition in Wagyu cattle increased BAT development in SAT, TVAT and PAT, while elevated maternal nutrition stimulated fetal SAT development compared with that of TVAT and PAT. DOI： 10.3389/fendo.2021.797680 Scopus その他リンク： https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85124724504&origin=inward
• Amino acid composition of amniotic fluid during the perinatal period reflects mother’s fat and carbohydrate intake2021 · 記述言語： 英語 掲載種別： 研究論文（学術雑誌） 出版者・発行元： Nutrients Dietary content during pregnancy is important because it is necessary for the growth of the fetus. With the assumption that the nutritional status of the fetus can be monitored by measuring amino acid concentrations in the amniotic fluid, we investigated whether the habitual dietary intake of pregnant women affected the composition of the amniotic fluid and the significance of perform-ing amniotic fluid analysis. The subjects were 34 mothers who delivered full‐term babies by cesarean section. Three biological samples were collected from the mothers: blood, cord blood, and am-niotic fluid. At the same time, the mothersʹ prenatal nutritional intake information was also rec-orded. When the amino acid contents of the samples were compared with the mothersʹ nutrient intake, many amino acids in the amniotic fluid were positively correlated with lipid intake, but not with protein intake. There was a negative correlation between lipid intake and carbohydrate intake, and the amino acid contents of the amniotic fluid were also negatively correlated with carbohydrate intake. The results of this study were consistent with those found in animal models, suggesting that the analysis of amniotic fluid may be a useful method to investigate the effects of habitual diet during human pregnancy on the fetus. DOI： 10.3390/nu13072136 Scopus その他リンク： https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85108212792&origin=inward
• Effects of low and high levels of maternal nutrition consumed for the entirety of gestation on the development of muscle, adipose tissue, bone, and the organs of Wagyu cattle fetuses.2021 · 記述言語： 英語 掲載種別： 研究論文（学術雑誌） 出版者・発行元： 公益社団法人 日本畜産学会 参加形態： 共同（副担当） DOI： 10.1111/asj.13600

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