東京科学大学 · 医歯学総合研究科 · 教授

研究キーワードinflammasomes・NLRP3・macrophage immunology・periodontal pathogens・multiple sclerosis・Toll-like receptor signaling・antimicrobial resistance・16S sequencing

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• Tokuju Okano, Hiroshi Ashida, Masayuki Tsukasaki, Tamako Iida, Masahiro Yamamoto, Hiroshi Takayanagi, Takeharu Sakamoto, Toshihiko Suzuki. Hypoxia drives progression of multiple sclerosis by enhancing the inflammasome activation in macrophages with Porphyromonas gingivalis infection. Cell Death Discov. 2025.06; 11 (1): 271. ( PubMed , DOI )2025
• Hsu Chen-Wei, Okano Tokuju, Niinuma Yuiko, Leewananthawet Anongwee, Iida Tamako, Onsoi Poramed, Boonyaleka Kotchakorn, Ashida Hiroshi, Suzuki Toshihiko. カスパーゼ-4とのNLRP3の複合体形成はTannerella forsythia感染によるインフラマソーム活性化のために必須である(A complex of NLRP3 with caspase-4 is essential for inflammasome activation by Tannerella forsythia infection) International Immunology. 2025.05; 37 (5): 261-271. ( 医中誌 )2025
• Ofosu Appiah F, Mahazu S, Prah I, Kawamura T, Ota Y, Nishikawa Y, Yoshida M, Suzuki M, Hoshino Y, Suzuki T, Ishino T, Ablordey A, Saito R. Emergence of Carbapenem-Resistant bla(POM-1) Harboring Pseudomonas otitidis Isolated from River Water in Ghana. Antibiotics (Basel, Switzerland). 2025.01; 14 (1): ( PubMed , DOI )2025
• Okano, T; Ashida, H; Komatsu, N; Tsukasaki, M; Iida, T; Iwasawa, M; Takahashi, Y; Takeuchi, Y; Iwata, T; Sasai, M; Yamamoto, M; Takayanagi, H; Suzuki, T. Caspase-11 mediated inflammasome activation in macrophages by systemic infection of A. actinomycetemcomitans exacerbates arthritis INTERNATIONAL JOURNAL OF ORAL SCIENCE. 2024.08; 16 (1): 54. ( PubMed , DOI )2024