東京科学大学 · 医歯学総合研究科 · 教授

研究キーワードtendon biology・tendon regeneration・mechanotransduction・periodontal ligament・chondrogenesis・musculoskeletal development・tendon stem cells・cartilage homeostasis

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• Masayasu Sega, Yutaro Uchida, Tomoki Chiba, Takahide Matsushima, Kohei Kita, Naoyuki Miyasaka, Hiroshi Asahara. Stage- and cluster-specific regulation of chondrogenic gene programs by Sox9 in mouse embryonic limb buds. iScience. 2026.03; 29 (3): 115074. ( PubMed , DOI )2026
• Lin Liu, Tomoki Chiba, Takahide Matsushima, Maiko Inotsume, Tomomi Kato, Yuichi Hiraoka, Hiroshi Asahara. Gene dosage-dependent roles of Mkx in postnatal tendon development and maintenance revealed by conditional deletion. Dev Biol. 2025.10; 526 15-25. ( PubMed , DOI )2025
• Suzu Chida, Tomoki Chiba, Yutaro Uchida, Takahide Matsushima, Ryota Kurimoto, Takayuki Miyazaki, Lisa Yagasaki, Satoshi Nakamura, Emiko Mihara, Junichi Takagi, Keiji Moriyama, Hiroshi Asahara. Impact of mechanotransduction on gene expression changes in periodontal ligament during orthodontic tooth movement. J Bone Miner Metab. 2025.02; ( PubMed , DOI )2025
• Yan Xie, Yapei Huang, Venkatlaxmi Chettiar, Tianzhou Xing, Steven K Huang, Bethany B Moore, Hiroshi Asahara, Peter W Abel, Yaping Tu. miR-146b disrupts the epidermal growth factor receptor/transforming growth factor β receptor profibrotic feedforward loop to inhibit lung fibroblast proliferation and differentiation. J Pharmacol Exp Ther. 2025.09; 392 (9): 103672. ( PubMed , DOI )2025