山口大学 · 細胞デザイン医科学研究所 · 助教

研究キーワードprotein phosphatase signaling・SET oncoprotein・mTOR signaling・neurite outgrowth・TGF-beta signaling

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• Protein phosphatase 6 promotes neurite outgrowth by promoting mTORC2 activity in N2a cells.
• The protein level of the tumour-promoting factor SET is regulated by cell density.
• PP2A inhibitor SET promotes mTORC1 and Bmi1 signaling through Akt activation and maintains the colony-formation ability of cancer cells.
• Protein phosphatase 6 promotes transforming growth factor-β signaling in mouse embryonic fibroblasts.

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