岐阜大学 · 医学系研究科 · 助教

研究关键词GPCR・Activation-Induced Cytidine Deaminase (AID)・RhoGEF・PLEKHG2

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• The Rho guanine nucleotide exchange factor PLEKHG1 is activated by interaction with and phosphorylation by Src family kinase member FYN.
• Threonine 680 Phosphorylation of FLJ00018/PLEKHG2, a Rho Family-specific Guanine Nucleotide Exchange Factor, by Epidermal Growth Factor Receptor Signaling Regulates Cell Morphology of Neuro-2a Cells*
• Identification of a Rho family specific guanine nucleotide exchange factor, FLJ00018, as a novel actin-binding protein
• Mechanism of inhibition of lipopolysaccharide-induced interferon-β production by 2-aminopurine

• 複数のCRISPR/Casを用いたDNA構造の改変と転写制御機構の解析
• 細胞リプログラミングへのシチジンデアミナーゼの関与
• 生体内enChIP法を用いたシチジンデアミナーゼ遺伝子発現調節機構の解明

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