北海道情報大学 · 総合情報学部 · 准教授

研究关键词neuroinflammation SPECT imaging・stroke rat models・arteriovenous malformation PET・norepinephrine transporter radiotracers・GAN-generated brain SPECT・cardiac sympathetic nerve PET・FDG-labeled stem cell imaging

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• Comparative analysis of peri-nidal cerebral blood flow and metabolism using a novel quantitative 15O-PET method in patients with arteriovenous malformations. Daisuke Maruyama, Hidehiro Iida, Kazuhiro Koshino, Jyoji Nakagawara, Yoshiaki Morita, Naoki Hashimura, Hisae Mori, Tetsu Satow, Jun C Takahashi, Tetsuya Fukuda, Koji Iihara, Hiroharu Kataoka. J Cereb Blood Flow Metab. 2024 Aug 11:271678X241270416. doi: 10.1177/0271678X241270416. Online ahead of print.（共著）2024
• [123I]CLINDE SPECT as a neuroinflammation imaging approach in a rat model of stroke, Makiko Ohshima, Tetsuaki Moriguchi, Jun-ichiro Enmi, Hidekazu Kawashima, Kazuhiro Koshino, Tsutomu Zeniya, Masahiro Tsuji, Hidehiro Iida. Experimental Neurology, Volume 378, 2024, 114843. （共著）2024
• Rationalizing the Binding Modes of PET Radiotracers Targeting the Norepinephrine Transporter. Anna Tutov,Xinyu Chen, Rudolf A. Werner Saskia Mühlig, Thomas Zimmermann,Naoko Nose, Kazuhiro Koshino, Constantin Lapa, Michael Decker, andTakahiro Higuchi. Pharmaceutics 2023, 15(2), 690（共著）2023
• Molecular Imaging-Derived Biomarker of Cardiac Nerve Integrity — Introducing High NET Affinity PET Probe 18F-AF78. Xinyu Chen, Rudolf A. Werner, Kazuhiro Koshino, Naoko Nose, Saskia Mühlig, Steven P Rowe, Martin G. Pomper, Constantin Lapa, Michael Decker and Takahiro Higuchi. Theranostics. 2022; 12(9): 4446–4458. （共著）2022

• 分子機能定量局所拡大撮像ＳＰＥＣＴ高感度化のための画像再構成アルゴリズムの開発
• 心筋血流量の高精度測定を実現するマルチスケール薬物動態モデルの開発
• 血管内病態診断のためのマルチモダリティ画像重ね合わせ技術の開発
• 超高解像度局所分子機能定量SPECT画質改善のための画像再構成アルゴリズムの開発

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