自治医科大学 · 分子病態治療研究センター · 助教

研究关键词placental inflammation・maternal age・pregnancy stress・fetal growth restriction・NLRP3 inflammasome・macrophage dysfunction・offspring metabolic programming・maternal hypertension

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• Advanced maternal age induces fetal growth restriction through decreased placental inflammatory cytokine expression and immune cell accumulation in mice.
• Severe maternal stress alters placental function, resulting in adipose tissue and liver dysfunction in offspring of mice.
• Gasdermin D regulates soluble fms-like tyrosine kinase 1 release in macrophages.
• Maternal hypertensive condition alters adipose tissue function and blood pressure sensitivity in offspring.

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