順天堂大学 · 医学研究科/医学部

研究关键词肺高血圧症・肺動脈リモデリング・肺動脈収縮・肺循環

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• Nagaoka T. Inhaled treprostinil for pulmonary hypertension due to interstitial lung disease. Respir Investig. 2025 Jul;63(4):608-609. F:2.0/CI: 0.2025
• Nagata Y, Nagaoka T, Terayama Y, Suzuki Y, Yoshida T, Kuriyama S, Shiota S, Sato M, Takahashi K. The Potential of Pulmonary Vasodilators as a Bridging Therapy for Lung Transplantation: Two Cases of Interstitial Pneumonia With Pulmonary Hypertension During the Waiting Period for Lung Transplantation. Respirol Case Rep. 2025;13(3):e70136. IF:0.800/CI: 0.2025
• Nishimaki T, Sasano H, Harada S, Takeshige T, Sandhu Y, Tanabe Y, Matsuno K, Nagaoka T, Ito J, Atsuta R, Ohuchi M, Yagishita S, Hamada A, Takahashi K, Harada N. Elevated mepolizumab levels in patients with severe asthma responsive to 1 year’s mepolizumab treatment. J Allergy Clin Immunol Glob. 2025 Jan 16;4(2):100410. IF: /CI: . Journal of Allergy and Clinical Immunology: Global Volume 4, Issue 2, May 2025,2025
• Sasano H, Harada N, Harada S, Takeshige T, Sandhu Y, Tanabe Y, Ishimori A, Matsuno K, Nagaoka T, Ito J, Chiba A, Akiba H, Atsuta R, Izuhara K, Miyake S, Takahashi K. Pretreatment circulating MAIT cells, neutrophils, and periostin predicted the real-world response after 1-year mepolizumab treatment in asthmatics. Allergol Int, 2024; 73(1): 94-106. IF:6.200/CI:2024

• 人工多能性幹細胞（iPS細胞）による肺動脈性肺高血圧症の血管内皮機能再生治療の試み
• 生体外増幅培養した血管内皮前駆細胞による肺高血圧症の血管内皮機能再生の試み
• 肺血管内皮細胞の内皮間葉転換におけるエクソソームの役割
• 血管内皮間葉系転換を標的とした新規の肺高血圧症治療薬の開発

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