順天堂大学 · 医学研究科/医学部

研究关键词autoimmune immunology・systemic lupus erythematosus・MAIT cells・vaccine immune memory・autoantibody pathology・arthritis immunopathology・monocyte biology

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• Kuga T, Chiba A, Murayama G, Hosomi K, Nakagawa T, Yahagi Y, Noto D, Kusaoi M, Kawano F, Yamaji K, Tamura N, Miyake S. Enhanced GATA4 expression in senescent systemic lupus erythematosus monocytes promotes high levels of IFNα production. Front Immunol 2024; 15:1320444.2024
• Sasano H, Harada N, Takeshige T, Sandhu Y, Tanabe Y, Ishimori A, Matsuno K, Nagaoka T, Ito J, Chiba A, Akiba H, Atsuta R, Izuhara K, Miyake S, Takahashi K. Pretreatment circulating MAIT cells, neutrophils, and periostin predicted the real-world response after 1-year mepolizumab treatment in asthmatics. Allergol Int 2024 ; 73(1):94-106.2024
• Shinjiro Kaieda, Takashi Kinoshita, Asako Chiba, Sachiko Miyake, Tomoaki Hoshino. IL-18 receptor-α signalling pathway contributes to autoantibody-induced arthritis via neutrophil recruitment and mast cell activation. Modern rheumatology Mod Rheumatol 2024; 34(3):500-508.2024
• Sandhu Y, Harada N, Sasano H, Harada S, Ueda S, Takeshige T, Tanabe Y, Ishimvori A, Matsuno K, Abe S, Nagaoka T, Ito J, Chiba A, Akiba H, Atsuta R, Izuhara K, Miyake S, Takahashi K. Pretreatment Frequency of Circulating Th17 Cells and FeNO Levels Predicted the Real-World Response after 1 Year of Benralizumab Treatment in Patients with Severe Asthma. Biomolecules. 2023;13(3):538.2023

• 腸管免疫による自己免疫制御の研究
• MAIT細胞を介した抗DNA抗体産生細胞の分化成熟メカニズムの解明
• 腸管免疫による自己免疫制御法の開発
• 免疫療法抵抗性MAFLD関連肝がんの形成機序解明を目指すマルチオミクス研究

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