順天堂大学 · 医学研究科/医学部 · 教授

研究关键词動脈硬化・膵β細胞・インスリン抵抗性・オートファジー・糖尿病学・インスリン

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• Mita T, Osonoi Y, Someya Y, Osonoi T, Saito M, Nakayama S, Ishida, H., Ishii, R., Gosho, M. and Watada, H.Relationship of carbohydrate intake proportion to cardiovascular events in Japanese people with type 2 diabetes mellitus. J Clin Endocrinol Metab. 2025.2025
• Himuro, M., Wakabayashi, Y., Taguchi, T., Katahira, T., Suzuki, L., Iida, H., Ogihara, T., Nishida, Y., Sasaki, S., Lynn, F. C., Hiraoka, Y., Oshima, S., Okamoto, R., Fujitani, Y., Watada, H., and Miyatsuka, T. (2024) Novel time-resolved reporter mouse reveals spatial and transcriptional heterogeneity during alpha cell differentiation. Diabetologia 67, 156-1692024
• Tomofuji, Y., Suzuki, K., Kishikawa, T., Shojima, N., Hosoe, J., Inagaki, K., Matsubayashi, S., Ishihara, H., Watada, H., Ishigaki, Y., BioBank Japan, P., Inohara, H., Murakami, Y., Matsuda, K., Okada, Y., Yamauchi, T., and Kadowaki, T. (2023) Identification of serum metabolome signatures associated with retinal and renal complications of type 2 diabetes. Commun Med (Lond) 3(1), 52023
• Philis-Tsimikas, A., Asong, M., Franek, E., Jia, T., Rosenstock, J., Stachlewska, K., Watada, H., and Kellerer, M. (2023) Switching to once-weekly insulin icodec versus once-daily insulin degludec in individuals with basal insulin-treated type 2 diabetes (ONWARDS 2): a phase 3a, randomised, open label, multicentre, treat-to-target trial. Lancet Diabetes Endocrinol 11, 414-425.2023

• 妊娠期膵β細胞量増大および妊娠糖尿病発症におけるオートファジーの意義の解明
• 糖尿病の病態解明に向けた膵α細胞新生・成熟機構の解明
• 膵β細胞オートファジー不全とp62陽性の封入体形成
• 膵β細胞特異的Atg7・p62二重欠損マウスの作製とその機能解析

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