鹿児島大学 · 医歯学総合研究科

研究关键词mitochondrial dysfunction・radiation biology・radiosensitization・KCC2 signaling・oxidative stress・neuroprotection・mutation detection・behavioral neuroscience

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• Takami Y., Tomita K., Igarashi K., Kuwahara Y., Kitanaka J., Kitanaka N., Roudkenar M.H., Roushandeh A.M., Saijo H., Kurimasa A., Sato T. . Amoxicillin, a β-lactam antibiotic, enhances cisplat2025 · 担当区分： 責任著者 記述言語： 英語 掲載種別： 研究論文（学術雑誌） 出版者・発行元： Biochemical and Biophysical Research Communications Amoxicillin (AMPC) is a commonly used as an antibiotic. This study showed that AMPC enhanced the anticancer effect of cisplatin by inducing mitochondrial dysfunction. Compared with controls, treatment of cervical cancer (HeLa) and oral squamous cell carcinoma (SAS) cells with 10 μg/mL AMPC significantly increased mitochondrial reactive oxygen species levels, decreased mitochondrial membrane potential, and reduced mitochondrial Fe2+ levels. This concentration is equivalent to the maximum blood levels of AMPC used in Helicobacter pylori eradication. The viability of HeLa and SAS cells was significantly reduced when cisplatin was administrated after AMPC; however, this effect was not observed in normal human fibroblast-like lung cells (VA-13) or human periodontal ligament fibroblast (HPLF) cells. AMPC did not enhance the anticancer effect of docetaxel. The AMPC-enhanced anticancer effect of cisplatin was blocked by the iron-chelating agent phenanthroline, indicating that the effect was primarily driven by ferroptosis, an iron-dependent form of cell death. The expression levels of the AMPC transporters PEPT1 and PEPT2 were higher in cancer cells such as HeLa and SAS than in normal cells. This phenomenon facilitates greater AMPC uptake and mitochondrial dysfunction in cancer cells. DOI： 10.1016/j.bbrc.2025.151888 Scopus PubMed その他リンク： https://www.sciencedirect.com/science/article/pii/S0006291X25006023
• 現代歯科薬理学 第7版2024 · 医歯薬出版 2024年1月 （ ISBN: 9784263456774 ）
• 高橋 将世, 桑原 義和, 富田 和男, 五十嵐健人, 上野 誠, 宮﨑 貴文, 杉本 義仁, 栗政 明弘, 佐藤 友昭2023 · 記述言語： 日本語
• Tomita K., Indo H.P., Sato T., Tangpong J., Majima H.J . Development of a sensitive double TaqMan Probe-based qPCR Angle-Degree method to detect mutation frequencies . Mitochondrion702023 · 記述言語： 日本語 出版者・発行元： Mitochondrion We designed a method to examine the mutation frequencies of the A3243G mutation of mitochondrial DNA (mtDNA) in patients with mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) syndrome. We performed a qPCR assay using the FAM and VIC TaqMan probes, which detect the 3243G (mutated) and 3243A (wild-type) sequences of mtDNA, respectively. The results obtained by “degree” in a series of differential mutation frequencies were used to plot a standard curve of the mutation frequency. The standard curve was then applied for qPCR assays of the desired samples. The standard deviation (%) of the samples calculated using the standard curve for the TaqMan probe was 2.4 ± 1.5%. This method could be used to examine mutation frequencies in the context of diabetes, aging, cancer, and neurodegenerative diseases. DOI： 10.1016/j.mito.2023.02.010 Scopus PubMed

• 抗菌薬のドラッグ・リポジショニングを活用した放射線抵抗性がん克服への挑戦2025 · 担当区分： 研究代表者 資金種別： 競争的資金 配分額： 4680000円 （ 直接経費： 3600000円 、 間接経費： 1080000円 ）
• 銀ナノ粒子による細胞膜とミトコンドリア動態変化に注目した新規がん治療戦略2024 · 配分額： 4550000円 （ 直接経費： 3500000円 、 間接経費： 1050000円 ）
• RAGEおよびリポカリン2を標的とした歯周病に対する新しい治療法の開発2023 · 担当区分： 研究代表者
• ミトコンドリアを標的としたフェロトーシス誘導による治療抵抗性がん克服への挑戦2022 · 担当区分： 研究代表者 資金種別： 競争的資金 配分額： 4290000円 （ 直接経費： 3300000円 、 間接経費： 990000円 ）

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