鹿児島大学 · 農水産獣医学域水産学系 · 准教授

研究关键词fish immunology・Takifugu genomics・sex determination・aquaculture genetics・lectins・host-parasite interactions・pufferfish evolution・mucosal immunity

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• Tasumi S., Ohira T., Kawazoe I., Suetake H., Suzuki Y., Aida K. . Primary structure and characteristics of a lectin from skin mucus of the Japanese eel Anguilla japonica . Journal of Biologica2026 · 記述言語： 英語 掲載種別： 研究論文（学術雑誌） 出版者・発行元： Journal of Biological Chemistry Two types of lactose-binding lectins, AJL-1 and AJL-2, were purified from the skin mucus extract of the Japanese eel Anguilla japonica by lactose affinity chromatography and subsequent gel filtration. The molecular masses of AJL-1 and AJL-2 were 16,091 and 31,743 Da, respectively. Intact AJL-1 was comprised of two identical 16-kDa subunits having blocked N termini and no disulfide bonds. AJL-2 was a homodimer with disulfide bonds. Based on the N-terminal amino acid sequence of the AJL-2 monomer, the nucleotide sequence of cDNA encoding this lectin was determined by 3′- and 5′-rapid amplification of cDNA ends. The deduced amino acid sequence showed ∼30% homology with C-type lectins, which bind to carbohydrates in a Ca2+-dependent manner. In addition, AJL-2 exhibited highly conserved consensus amino acid residues of the C-type carbohydrate recognition domain, although this lectin showed Ca2+-independent activity. Gene expression of AJL-2 was de. tected only in the skin by Northern blot analysis, and this lectin localization was demonstrated in the club cells by immunohistochemistry. These results indicate that AJL-2 is secreted on the body surface and function as a component of skin mucus. AJL-2 agglutinated Escherichia coli and suppressed its growth, suggesting that this lectin is involved in host defense. DOI： 10.1074/jbc.M202648200 Web of Science Scopus
• Rana KMS, Matsunaga R, Sato Y, Suetake H, Kikuchi K, Ohtsuka S, Kotani T, Tasumi S . Identification of genes expressed in the pectoral fins and skin of Takifugu rubripes to reveal candi2025 · 担当区分： 最終著者, 責任著者 記述言語： 英語 掲載種別： 研究論文（学術雑誌） DOI： 10.1016/j.cbd.2025.101731 PubMed
• Sato Y, Matsunaga R, Tasumi S, Mizuno N, Nakane M, Hosoya S, Yamamoto A, Nakamura O, Tsutsui S, Shiozaki K, Kikuchi K . L-fucoside localization in the gills of the genus Takifugu and it2023 · 担当区分： 責任著者 記述言語： 英語 掲載種別： 研究論文（学術雑誌） DOI： 10.1016/j.bbagen.2023.130467 PubMed
• Ohtsuka S, Nishida Y, Hirano K, Fuji T, Kaji T, Kondo Y, Komeda S, Tasumi S, Koike K, Boxshall GA . The cephalothoracic sucker of sea lice (Crustacea: Copepoda: Caligidae): The function2021 · 記述言語： 英語 掲載種別： 研究論文（学術雑誌） DOI： 10.1016/j.asd.2021.101046 PubMed

• マレーシア産海産有用動物のヒル類・甲殻類寄生虫の宿主認識と疾病媒介の可能性の調査2024 · 担当区分： 研究代表者 資金種別： 競争的資金
• 魚類寄生単生類の宿主認識分子機構2022 · 担当区分： 研究代表者 資金種別： 競争的資金
• マレーシア産海産有用魚類・無脊椎動物の甲殻類・単生類寄生虫の宿主特異性メカニズム2020 · 資金種別： 競争的資金
• ウオジラミ類の生活史、宿主特異性、生理機能の普遍性と可変性2019 · 担当区分： 研究分担者 資金種別： 競争的資金

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