近畿大学 · 近畿大学奈良病院

研究关键词TET2 mutation・myeloproliferative neoplasms・myeloma-initiating cells・EGFR-mutant lung cancer・hematopoietic stem cells・megakaryopoiesis・reactive iron・relapsed multiple myeloma

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• Excessive Reactive Iron Impairs Hematopoiesis by Affecting Both Immature Hematopoietic Cells and Stromal Cells.
• BCR-ABL陰性骨髄増殖性腫瘍においてTET2変異は生存に対する予後不良因子である(TET2 mutation is a poor prognostic factor for survival in BCR-ABL-negative MPN patients)
• Chlorpromazine cooperatively induces apoptosis with tyrosine kinase inhibitors in EGFR-mutated lung cancer cell lines and restores the sensitivity to gefitinib in T790M-harboring resistant cells.
• CD34陽性ヒト骨髄腫幹細胞の同定と特性解析(Identification and characterization of CD34+ myeloma cell population as myeloma-initiating cells)

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