京都大学 · 薬学部・薬学研究科 · 教授

研究关键词targeted drug delivery・macrophage targeting・bubble lipoplex・gene transfection・microfluidic screening・anti-inflammatory biomaterials・mannosylated emulsions

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• In Vitro Cellular Gene Delivery Employing a Novel Composite Material of Single-Walled Carbon Nanotubes Associated With Designed Peptides With Pegylation.Journal of pharmaceutical sciences,
• Tumour-associated macrophages targeted transfection with NF-κB decoy/mannose-modified bubble lipoplexes inhibits tumour growth in tumour-bearing mice.Journal of drug targeting,
• Evaluation of inflammatory responses due to small interfering RNA transfer using unmodified- and mannose-modified bubble lipoplexes with ultrasound exposure in primary cultured macrophagesJOURNAL OF DRUG TARGETING,
• Enhanced Anti-Inflammation of Inhaled Dexamethasone Palmitate Using Mannosylated Liposomes in an Endotoxin-Induced Lung Inflammation ModelMOLECULAR PHARMACOLOGY,

• ネットワークトキシコロジーに基づくDDSキャリアの安全性評価体系の構築
• ヘパリンナノ粒子の多重標的機能を巧妙に利用した画期的関節リウマチ炎治療法の開発
• ＰＥＧ脂質と外部刺激を利用した新規細胞膜表面修飾法の開発
• 転写制御による炎症性疾患に対する新規治療法の開発

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