京都大学 · 医学部・医学研究科

研究关键词colorectal cancer・breast cancer organoids・tumor heterogeneity・cancer stem-like cells・melanoma progression・NOTCH signaling・neuroendocrine carcinoma・STAT3 signaling

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• Growth pattern of de novo small clusters of colorectal cancer is regulated by Notch signaling at detachmentCancer Science,
• Patient-Derived Tumor Organoids to Model Cancer Cell Plasticity and Overcome Therapeutic Resistance
• Clonal Origin and Lineage Ambiguity in Mixed Neuroendocrine Carcinoma of the Uterine CervixThe American Journal of Pathology,
• Xenograft-Derived Human Breast Cancer Organoids Can Form Chimeras with Host Mouse Mammary Epithelial Cells Which Promote Tumor Cell Proliferation

• Functional single-cell analysis of the stem cell plasticity associated with drug-tolerant persister cells in colorectal cancer
• 細胞傷害性がん治療法による残存がん細胞の再生メカニズムの解明と標的化
• 胸腺上皮性腫瘍オルガノイドを用いた分子標的薬テーラーメイド治療の開発
• 薬剤耐性大腸がん緩慢増殖細胞の遺伝的脆弱性の解明と標的化

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