京都大学 · 工学部・工学研究科 · 准教授

研究关键词CNNM magnesium transporters・magnesium homeostasis・CorC transporter・TRPM6・nucleoredoxin signaling・Wnt/beta-catenin signaling・planar cell polarity・PRL-CNNM interaction・epithelial magnesium extrusion・Caenorhabditis elegans gonadogenesis

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• AI-driven mechanistic analysis of conformational dynamics in CNNM/CorC Mg2+ transporters.1993 · Structure (London, England : 1993),
• Membrane protein CNNM4-dependent Mg2+ efflux suppresses tumor progressionJOURNAL OF CLINICAL INVESTIGATION,
• Development of a high-throughput screening system targeting the protein-protein interactions between PRL and CNNM.Scientific reports,
• An interaction between human Sec63 and nucleoredoxin may provide the missing link between the SEC63 gene and polycystic liver diseaseFEBS Letters,

• Lysosomal exocytosisを基軸としたがん細胞の酸性環境適応機構の全容解明
• Lysosomal exocytosisを介した細胞の酸性環境適応機構
• Nucleoredoxinファミリーによる活性酸素応答機構
• 細胞外プロトン場形成によるpHシグナル

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