明治薬科大学 · 未分類 · 助教

研究关键词CYP3A humanized mice・MDR1 humanized mice・drug-drug interactions・hepatic metabolism・brain drug distribution・blood-brain barrier・PXR humanized rats・mass spectrometry imaging・intestinal CYP3A inhibition・triazolam pharmacokinetics

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• Double-humanized Rats for CYP3A and PXR as an Improved Model for Analyzing Drug-drug Interactions Mediated by CYP3A4.
• Induction of hepatic CYP3A4 expression by cholesterol and cholic acid: Alterations of gene expression, microsomal activity, and pharmacokinetics.
• CYP3A4 Induction in the Liver and Intestine of Pregnane X Receptor/CYP3A-Humanized Mice: Approaches by Mass Spectrometry Imaging and Portal Blood Analysis.
• Deadenylase-dependent mRNA decay of GDF15 and FGF21 orchestrates food intake and energy expenditure.

• 抗がん剤代謝酵素CYP3A活性の個人差による活性代謝物増加を介した肝毒性発現機序
• 脂質ナノ粒子工学と染色体工学を融合した遺伝子導入モデルによるCYP3A機能解明

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