横浜薬科大学 · 薬学教育センター

研究关键词●微生物の産生する酵素阻害抗癌薬の開発研究・●遺伝子の機能解析に応用可能な新規ベクターの開発・改良

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• 2. Antiviral activities against herpes simplex virus type 1 by HPH derivatives and their structure-activity relationships. Hosono T ., Yokomizo K., Hamasaki A., Okamoto Y., Okawara T., Otsuka M., Mukai R., Suzuki K. Bioorg. Med. Chem. Lett., 18, 371-374 (2008).2008
• 3. Rapid construction of small interfering RNA-expressing adenoviral vectors on the basis of direct cloning of short hairpin RNA-coding DNAs. Mizuguchi H., Funakoshi N., Hosono T ., Sakurai F., Kawabata K., Yamaguchi T., Hayakawa T. Hum Gene Ther., 18, 74-80 (2007).2007
• 4. RNA interference of PPARgamma using fiber-modified adenovirus vector efficiently suppresses preadipocyte-to-adipocyte differentiation in 3T3-L1 cells. Hosono T ., Mizuguchi H., Katayama K., Koizumi N., Kawabata K., Yamaguchi T., Nakagawa S., Watanabe Y., Mayumi T., Hayakawa T. Gene, 348, 157-165 (2005).2005
• 5. Approaches to improving the kinetics of adenovirus-delivered genes and gene products. Xu Z.L., Mizuguchi H., Sakurai F., Koizumi N., Hosono T ., Kawabata K., Watanabe Y., Yamaguchi T., Hayakawa T. Adv. Drug. Deliv. Rev., 57, 781-802 (2005).2005

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