奥羽大学 · 薬学部 · 助教

研究关键词Innate Immunity・Toll-Like Receptor Signaling・TLR4・TLR9・B-Cell Signaling・Lipopolysaccharide Recognition・Monoclonal Antibodies・Myeloid Cell Regulation・Antigen Presentation

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• Lipopolysaccharide (LPS)-binding protein stimulates CD14-dependent Toll-like receptor 4 internalization and LPS-induced TBK1-IKKϵ-IRF3 axis activation.
• CD20 and CD19 promote proliferation driven by the IgM-TLR9-L265P MyD88 complex.
• Impaired antigen-specific lymphocyte priming in mice after Toll-like receptor 4 activation via induction of monocytic myeloid-derived suppressor cells.
• An inhibitory epitope of human Toll-like receptor 4 resides on leucine-rich repeat 13 and is recognized by a monoclonal antibody.

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