琉球大学 · 医学部 · 講師

研究关键词post-intensive care syndrome・severe COVID-19 rehabilitation・ICU nutrition・long-term functional recovery・quality of life・physical impairment prevention

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• Two-year trajectory of functional recovery and quality of life in post-intensive care syndrome: a multicenter prospective observational study on mechanically ventilated patients with coronavirus disease-19.2025 · Hatakeyama J, Nakamura K, Inoue S, Liu K, Yamakawa K, Nishida T, Ohshimo S, Hashimoto S, Kanda N, Aso S, Suganuma S, Maruyama S, Ogata Y, Takasu A, Kawakami D, Shimizu H, Hayakawa K, Yoshida T, Oshima T, Fuchigami T, Yawata H, Oe K, Kawauchi A, Yamagata H, Harada M, Sato Y, Nakamura T, Sugiki K, Hakozaki T, Beppu S, Anraku M, Kato N, Iwashita T, Kamijo H, Kitagawa Y, Nagashima M, Nishimaki H, Tokuda K, Nishida O
• Early Rehabilitation Interventions by Physical Therapists for Severe COVID-19 Patients Were Associated With Decreased Incidence of Post-ICU Physical Impairment.2025 · Oku S, Hatakeyama J, Liu K, Tojo K, Idei M, Inoue S, Yamakawa K, Nishida T, Ohshimo S, Hashimoto S, Maruyama S, Ogata Y, Kawakami D, Shimizu H, Hayakawa K, Fujino Y, Oshima T, Fuchigami T, Yawata H, Oe K, Kawauchi A, Yamagata H, Harada M, Sato Y, Nakamura T, Sugiki K, Hakozaki T, Beppu S, Anraku M, Kato N, Iwashita T, Kamijo H, Kitagawa Y, Nagashima M, Nishimaki H, Tokuda K, Nishida O, Nakamura K
• Relationship between critical care nutrition and post-intensive care syndrome in surviving ventilated patients with COVID-19: a multicenter prospective observational study2024 · <p>The impact of nutrition therapy in the acute phase on post-intensive care syndrome (PICS) remains unclear. We conducted a multicenter prospective study on adult patients with COVID-19 who required mechanical ventilation for more than three days. The questionnaire was mailed after discharge. Physical PICS, defined as less than 90 points on the Barthel index (BI), was assigned as the primary outcome. We examined the types of nutrition therapy in the first week that affected PICS components. 269 eligible patients were evaluated 10 months after discharge. Supplemental parenteral nutrition (SPN) >400 ‍kcal/day correlated with a lower occurrence of physical PICS (10% vs 21.92%, <i>p</i> = 0.042), whereas the amounts of energy and protein provided, early enteral nutrition, and a gradual increase in nutrition delivery did not, and none correlated with cognitive or mental PICS. A multivariable regression analysis revealed that SPN had an independent impact on physical PICS (odds ratio 0.33, 95% CI 0.12–0.92, <i>p</i> = 0.034), even after adjustments for age, sex, body mass index and severity. Protein provision ≥1.2 ‍g/kg/day was associated with a lower occurrence of physical PICS (odds ratio 0.42, 95% CI 0.16–1.08, <i>p</i> = 0.071). In conclusion, SPN in the acute phase had a positive impact on physical PICS for ventilated patients with COVID-19.</p>
• Post COVID-19 condition in hospitalized survivors after one year of infection during the Alpha- and Delta-variant dominant waves in Japan: COVID-19 Recovery Study II2021 · <p><b>Background:</b> Evidence of post-COVID-19 condition (PCC) in the Alpha- and Delta-variant dominant waves is limited.</p><p><b>Methods:</b> In a nationwide multicenter cohort study in collaboration with 20 hospitals, we collected data using self-administered questionnaires and electronic medical records of participants aged 20 or more diagnosed with COVID-19, hospitalized between April 1, 2021 and September 30, 2021, and discharged alive. Descriptive statistics were analyzed for PCC and mental health (HADS anxiety and depression scores), comparing Alpha- and Delta-variant dominant waves.</p><p><b>Results:</b> We analyzed 1,040 patients (median age, 57 [IQR 49–66] years; men, 66.2%). Of the respondents, 45.4% had at least one PCC symptom 1 year after infection. The common symptoms included dyspnea (20.7%), fatigue/malaise (17.6%), muscle weakness (15.4%), decrease in concentration (13.4%), and sleep disorder (13.3%), followed by brain fog (8.4%). Among patients with PCC, 14.0% had anxiety (HADS-Anxiety ≥11), and 18.6% had depression (HADS-Depression ≥11), with four times higher proportions than those without PCC; only small variations by age, sex, and waves were observed. Associated factors for PCC were age 40 years or over, women, severity of COVID-19 during hospitalization, ex-smokers who quit smoking before COVID-19 infection and being infected during the Delta-variant dominant wave.</p><p><b>Conclusion:</b> The study described the prevalence of PCC, associated factors, and mental health of COVID-19 survivors hospitalized during the Alpha- and Delta-variant dominant waves in Japan. Further follow-up will be conducted to examine the longer-term impact of COVID-19 on PCC, complications, daily life, and socioeconomic status.</p>

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