信州大学 · 医学科/医学部 · 教授

研究关键词vascular metastagenesis・citrullinated fibrinogen・serum amyloid A complexes・CXCR4 signaling・p38 MAP kinase・focal adhesion kinase・lung metastasis niches・vascular permeability

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• Primary tumours modulate innate immune signalling to create pre-metastatic vascular hyperpermeability foci.
• Endothelial focal adhesion kinase mediates cancer cell homing to discrete regions of the lungs via E-selectin up-regulation.
• Citrullinated fibrinogen-SAAs complex causes vascular metastagenesis
• Tumor-mediated upregulation of chemoattractants and recruitment of myeloid cells pre-determines lung metastasis.

• 細胞外mRNAのバイオロジー

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