昭和薬科大学 · 医薬分子化学研究室 · 助教

研究关键词HIV-1 entry inhibitors・HIV-1 fusion inhibitors・CD4 mimics・anti-HIV peptides・CXCR4 ligands・peptidomimetics・protein labeling probes

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• Cyclization Reaction-Based Turn-on Probe for Covalent Labeling of Target Proteins. Hiroyuki Kojima, Yuki Fujita, Ryosuke Takeuchi, Yuka Ikebe, Nami Ohashi, Keiko Yamamoto & Toshimasa Itoh* Cell Chem. Biol. 27 334-349 20202020
• Bivalent HIV-1 Fusion Inhibitors Based on Peptidomimetics. Takuya Kobayakawa, Kento Ebihara, Kohei Tsuji, Takuma Kawada, Masayuki Fujino, Yuzuna Honda, Nami Ohashi, Tsutomu Murakami & Hirokazu Tamamura* Bioorg. Med. Chem. 28 115812 20202020
• Synthesis of Hydrophilic Caged DAG-lactones for Chemical Biology Applications. Takuya Kobayakawa, Hikaru Takano, Takahiro Ishii, Kohei Tsuji, Nami Ohashi, Wataru Nomura, Toshiaki Furuta & Hirokazu Tamamura* Org. Biomol. Chem. 18 4217-4223 20202020
• Endocannabinoid hydrolysis inhibition unmasks that unsaturated fatty acids induce a robust biosynthesis of 2-arachidonoylglycerol and its congeners in human myeloid leukocytes. Caroline Turcotte, Anne‐Sophie Archambault, Élizabeth Dumais, Cyril Martin, Marie‐Renée Blanchet, Elyse Bissonnette, Nami O2020

• 蛍光を用いたPKCリガンドの2段階結合評価系の構築とバイオセンサーへの応用
• ペプチドミメティックを活用した中分子型創薬リードの創製

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