高崎健康福祉大学 · 薬学部 · 講師

研究关键词GATA1・GATA2・hematopoietic development・mast cells・erythroid differentiation・urogenital development・CAKUT・BMP4・gene regulation・Xenopus embryos

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• The Gata2 repression during 3T3-L1 preadipocyte differentiation is dependent on a rapid decrease in histone acetylation in response to glucocorticoid receptor activation.
• GATA2 and PU.1 collaborate to activate the expression of the mouse Ms4a2 gene encoding FcϵRIβ through distinct mechanisms.
• Mast cell deficiency results in the accumulation of preadipocytes in adipose tissue in both obese and non-obese mice
• GATA2 is critical for the maintenance of cellular identity in differentiated mast cells derived from mouse bone marrow

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