帝京大学 · 薬学部 · 助教

研究关键词PCIF1/CAPAM・m6Am methylation・mRNA stability・type I interferon signaling・IRF3 regulation・RNA epitranscriptomics・transcription-dependent promoter recruitment

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• Cap-Specific m6Am Methyltransferase PCIF1/CAPAM Regulates mRNA Stability of RAB23 and CNOT6 through the m6A Methyltransferase Activity.
• The cap-specific m6A methyltransferase, PCIF1/CAPAM, is dynamically recruited to the gene promoter in a transcription-dependent manner.
• PCIF1 Attenuates Type I Interferon Induction by Inhibiting IRF3 Activation in a Methyltransferase-Independent Manner.

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