帝京大学 · 薬学部 · 准教授

研究关键词Nobiletin pharmacology・Polymethoxyflavonoids・MEK inhibition・Matrix metalloproteinase inhibition・Fibrosarcoma metastasis・Retinal arterioles・Lens epithelial cells・Flavonoid therapeutics

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• Nobiletin metabolites: Synthesis and inhibitory activity against matrix metalloproteinase-9 production
• Inhibition of activator protein-1 binding activity and phosphatidylinositol 3-kinase pathway by nobiletin, a polymethoxy flavonoid, results in augmentation of tissue inhibitor of metalloproteinases-1 production and suppression of production of matrix metalloproteinases-1 and -9 in human fibrosarcoma HT-1080 cells.
• Comprehensive Synthesis of Side-Chain Fluorinated 2α-[2-(Tetrazol-2-yl)ethyl]-1α,25-dihydroxyvitamin D3 Analogs and Preliminary Biological Activities.
• Semiquantitative analysis of protein expression in heated rat lens using shotgun proteomics.

• 新規フラボノイド化合物ライブラリーを基盤とする糖尿病網膜症予防薬の創薬研究
• 眼疾患の薬物治療への応用を志向したフラボン類の合成及び構造活性相関研究

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