帝京大学 · 薬学部 · 教授

研究关键词obesity and diabetes・adipocyte fatty acid-binding protein・PAI-1 and fibrinolysis・circadian regulation of coagulation・acidic sialidase・metabolic inflammation

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• Sole existence of antithrombin antibody in patients with systemic lupus erythematosus showing tendency of its antigenic determinants directing against exosite II (antithrombin/heparin binding site) of thrombin.
• Regulatory functions of phospholipase A(2)
• Fas-induced arachidonic acid release is mediated by Ca2+-independent phospholipase A(2) but not cytosolic phospholipase A(2) which undergoes proteolytic inactivation
• Prostaglandin E-2 amplifies cytosolic phospholipase A(2)- and cyclooxygenase-2-dependent delayed prostaglandin E-2 generation in mouse osteoblastic cells - Enhancement by secretory phospholipase A(2)

• Relationship between lipid metabolism and clock genes in mammalian peripheral tissues
• Alteration of lipid metabolism in diseases
• 疾患における脂質代謝異常の解析
• 体内時計と脂質代謝の関係

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