帝京大学 · 薬学部 · 教授

研究关键词Xenobiotics・Transporter・Orphan molecule・Cell membrane・Blood-tissue barrier・オーファン分子・トランスポーター・消化管吸収

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• Quantitative Determination of Luminal and Abluminal Membrane Distributions of Transporters in Porcine Brain Capillaries by Plasma Membrane Fractionation and Quantitative Targeted Proteomics
• Construction and Functional Evaluation of a Three-Dimensional Blood-Brain Barrier Model Equipped With Human Induced Pluripotent Stem Cell-Derived Brain Microvascular Endothelial Cells.
• Total Synthesis of Decahydroquinoline Poison Frog Alkaloids ent-cis-195A and cis-211A.
• Proximity of periplasmic loops in the metal-tetracycline/H+ antiporter of Escherichia coli observed on site-directed chemical cross-linking

• Study of Orphan SLC Transporter in the Intestine and Kidney
• 組織関門における新規インフラックス分子実体の同定と薬効・毒性予測への展開
• Elucidation of Physiological Roles of Orphan ABC Transporter
• 新規カチオン性薬物輸送機構におけるオーファン分子の役割解明と創薬への展開

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