東京科学大学 · 総合研究院

研究关键词mitophagy pathway・pexophagy regulation・PINK1 Parkin pathway・OPTN ATG9A axis・p97 VCP・DJ-1 mutants

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• Watanabe A, Ogiwara S, Saito M, Mishima M, Yamashina M, Ishitani R, Ito Y, Tanaka K, Koyano F, Yamano K, Kosako H, Moriwaki Y, Matsuda N. The reaction mechanism for glycolysis side product degradation by Parkinson's disease-linked DJ-1. The Journal of cell biology. 2025.08; 224 (8): ( PubMed , DOI )2025
• Fumika Koyano, Noriyuki Matsuda. Quality control of ABCD3 by the VCP-FAF2 complex suppresses excessive pexophagy. Autophagy. 2025.02; 21 (5): 1169-1170. ( PubMed , DOI )2025
• Koyano F, Yamano K, Hoshina T, Kosako H, Fujiki Y, Tanaka K, Matsuda N. AAA+ ATPase chaperone p97/VCP(FAF2) governs basal pexophagy. Nature communications. 2024.10; 15 (1): 9347. ( PubMed , DOI )2024
• Aiko Watanabe, Fumika Koyano, Kenichiro Imai, Yohei Hizukuri, Shizuka Ogiwara, Tomoya Ito, Jun Miyamoto, Chihiro Shibuya, Mayumi Kimura, Kazuya Toriumi, Chie Motono, Makoto Arai, Keiji Tanaka, Yoshinori Akiyama, Koji Yamano, Noriyuki Matsuda. The origin of esterase activity of Parkinson's disease causative factor DJ-1 implied by evolutionary trace analysis of its prokaryotic homolog HchA. J Biol Chem. 2024.06; 300 (7): 107476. ( PubMed , DOI )2024

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