東北大学 · 加齢医学研究所

研究关键词transcription activator-like effectors・RNA-binding proteins・methylated DNA recognition・m6A detection・gene regulation・engineered nucleic acid binders・split luciferase complementation・macropinocytosis-mediated delivery

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• Sequence-specific recognition of methylated DNA by an engineered transcription activator-like effector proteinShogo Tsuji, Shiroh Futaki, Miki Imanishi
• Sleep-wake patterns are altered with age, Prdm13 signaling in the DMH, and diet restriction in mice.Shogo Tsuji, Cynthia S Brace, Ruiqing Yao, Yoshitaka Tanie, Hirobumi Tada, Nicholas Rensing, Seiya Mizuno, Julio Almunia, Yingyi Kong, Kazuhiro Nakamura, Takahisa Furukawa, Noboru Ogiso, Shinya Toyokuni, Satoru Takahashi, Michael Wong, Shin-Ichiro Imai, Akiko Satoh
• Modified nucleobase-specific gene regulation using engineered transcription activator-like effectors.Tsuji S, Imanishi M
• Zn(II) Binding and DNA Binding Properties of Ligand-Substituted CXHH-Type Zinc Finger ProteinsMiki Imanishi, Kazushi Matsumura, Shogo Tsuji, Tomohiro Nakaya, Shigeru Negi, Shiroh Futaki, Yukio Sugiura

• 視床下部PRDM13による睡眠・老化制御メカニズムの解明辻 将吾
• 神経細胞の脂質恒常性変化に基づく加齢に伴う高脂肪食感受性増大機構の解明辻 将吾
• 睡眠の質を制御する脳内タンパク質の同定-加齢による睡眠の質低下の予防を目指して-辻 将吾
• 加齢性睡眠断片化の分子基盤：Prdm13転写ネットワークの統合解析辻 将吾

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