東北大学 · 生命科学研究科

研究关键词LRRK2・Rab GTPases・Parkinson disease・lysosomal stress response・trans Golgi morphology・Rab29 phosphorylation・exosome regulation

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• Two roads diverged in a cell: insights from differential exosome regulation in polarized cellsTadayuki Komori, Mitsunori Fukuda
• LRRK2 and its substrate Rab GTPases are sequentially targeted onto stressed lysosomes and maintain their homeostasisTomoya Eguchi, Tomoki Kuwahara, Maria Sakurai, Tadayuki Komori, Tetta Fujimoto, Genta Ito, Shin-ichiro Yoshimura, Akihiro Harada, Mitsunori Fukuda, Masato Koike, Takeshi Iwatsubo
• An Update on the Interplay between LRRK2, Rab GTPases and Parkinson’s DiseaseTadayuki Komori, Tomoki Kuwahara
• Parkinson's disease-associated mutant LRRK2 phosphorylates Rab7L1 and modifies trans-Golgi morphologyTetta Fujimoto, Tomoki Kuwahara, Tomoya Eguchi, Maria Sakurai, Tadayuki Komori, Takeshi Iwatsubo

• パーキンソン病関連因子Rab39B依存的なエクソソームの機能と制御機構の解明小森 禎之
• Rab7L1の生理的機能解析から迫るリソソームストレス応答機構の解明小森 禎之

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