東北大学 · 医学部 / 医学系研究科 · 助教

研究关键词lung ischemia-reperfusion injury・NRF2-activated lung cancer・drug resistance・enhancer remodeling・tumor-initiating activity・inflammatory tissue repair・CEBPB signaling・non-small cell lung cancer

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• Glucocorticoid receptor signaling represses the antioxidant response by inhibiting histone acetylation mediated by the transcriptional activator NRF2.Md Morshedul Alam, Keito Okazaki, Linh Thi Thao Nguyen, Nao Ota, Hiroshi Kitamura, Shohei Murakami, Hiroki Shima, Kazuhiko Igarashi, Hiroki Sekine, Hozumi Motohashi
• The Complex Roles of Redox and Antioxidant Biology in CancerMakiko Hayashi, Keito Okazaki, Thales Papgiannakopoulos, Hozumi Motohashi
• Enhancer remodeling promotes tumor-initiating activity in NRF2-activated non-small cell lung cancers.Keito Okazaki, Hayato Anzawa, Zun Liu, Nao Ota, Hiroshi Kitamura, Yoshiaki Onodera, Md Morshedul Alam, Daisuke Matsumaru, Takuma Suzuki, Fumiki Katsuoka, Shu Tadaka, Ikuko Motoike, Mika Watanabe, Kazuki Hayasaka, Akira Sakurada, Yoshinori Okada, Masayuki Yamamoto, Takashi Suzuki, Kengo Kinoshita, Hiroki Sekine, Hozumi Motohashi
• O-GlcNAcylation Signal Mediates Proteasome Inhibitor Resistance in Cancer Cells by Stabilizing NRF1.Sekine, H., Okazaki, K., Kato, K., Alam, M. M., Shima, H., Katsuoka, F., Tsujita, T., Suzuki, N., Kobayashi A., Igarashi, K., Yamamoto, M., and Motohashi, H.

• がんの悪性化をもたらす遺伝子発現ドミノ効果の検証と意義の解明岡崎 慶斗
• Regnase-1による転写後制御が創出するがん悪性化機構の解明岡崎 慶斗
• 難治性がんにおけるRegnase-1によるRNA分解調節機構の検証岡崎 慶斗

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