東北大学 · 薬学部 / 薬学研究科 · 准教授

研究关键词薬物代謝・PGx・毒性学・医療薬学

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• Dihydropyrazine induces endoplasmic reticulum stress and inhibits autophagy in HepG2 human hepatoma cells
• The effect of dihydropyrazines on lipopolysaccharide-stimulated human hepatoma HepG2 cells via regulating the TLR4-MyD88-mediated NF-κB signaling pathway.
• Comprehensive Characterization of Mouse UDP-Glucuronosyltransferase (Ugt) Belonging to the Ugt2b Subfamily: Identification of Ugt2b36 as the Predominant Isoform Involved in Morphine Glucuronidation.
• Oxidative stress and cellular toxicity induced by dihydropyrazine: a comparative study with other Maillard reaction products.

• Effect of dexamethasone treatment on cytochrome P450 3A-UDP-glucuronosyltransferase 1A interaction in rat liver
• 「酵素複合体」に着目した柔軟性の高い薬物代謝活性の変動メカニズム
• 薬物代謝酵素複合体の定量的解析による個体差の解明
• UDP-グルクロン酸転移酵素の細胞質ペプチドによる空間を超えた酵素活性の制御： 膜脂質との相互作用

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