東北大学 · 工学部 / 工学研究科 · 助教

研究关键词cell-free enzyme screening・redox-responsive hydrogel beads・directed evolution・scaffold protein selection・high-throughput screening・next-generation sequencing・artificial compartments・enzyme engineering

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• Combination Informatic and Experimental Approach for Selecting Scaffold Proteins for Development as Antibody MimeticsTomoyuki Ito, Hafumi Nishi, Tomoshi Kameda, Mayu Yoshida, Reito Fukazawa, Sakiya Kawada, Hikaru Nakazawa, Mitsuo Umetsu
• Structure reveals a regulation mechanism of plant outward-rectifying K+ channel GORK by structural rearrangements in the CNBD-Ankyrin bridge.Taro Yamanashi, Yuki Muraoka, Tadaomi Furuta, Tsukasa Kume, Natsuko Sekido, Shunya Saito, Shota Terashima, Takeshi Yokoyama, Yoshikazu Tanaka, Atsushi Miyamoto, Kanane Sato, Tomoyuki Ito, Hikaru Nakazawa, Mitsuo Umetsu, Ellen Tanudjaja, Masaru Tsujii, Ingo Dreyer, Julian I Schroeder, Yasuhiro Ishimaru, Nobuyuki Uozumi
• Discovery and affinity maturation of antibody fragments from an unfavorably enriched phage display selection by deep sequencing and machine learningSakiya Kawada, Yoichi Kurumida, Tomoyuki Ito, Thuy Duong Nguyen, Hafumi Nishi, Hikaru Nakazawa, Yutaka Saito, Tomoshi Kameda, Koji Tsuda, Mitsuo Umetsu
• Selection of target-binding proteins from the information of weakly enriched phage display libraries by deep sequencing and machine learningTomoyuki Ito, Thuy Duong Nguyen, Yutaka Saito, Yoichi Kurumida, Hikaru Nakazawa, Sakiya Kawada, Hafumi Nishi, Koji Tsuda, Tomoshi Kameda, Mitsuo Umetsu

• 機械学習が道先案内する進化分子工学：がん治療抗体のスマート成熟プロセス提案梅津 光央, 亀田 倫史, 齋藤 裕, 津田 宏治, 伊藤 智之

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