東北大学 · 医学イノベーション研究所 · 講師

研究关键词hematopoietic stem cells・bone marrow niche・stem cell self-renewal・caloric restriction・hepatic steatosis・insulin resistance・adiponectin・EP4 signaling

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• Machine Learning of Hematopoietic Stem Cell Divisions from Paired Daughter Cell Expression Profiles Reveals Effects of Aging on Self-Renewal.Fumio Arai*, Patrick S Stumpf*, Yoshiko M Ikushima*, Kentaro Hosokawa, Aline Roch, Matthias P Lutolf, Toshio Suda, Ben D MacArthur
• An antisense transcript transcribed from Irs2 locus contributes to the pathogenesis of hepatic steatosis in insulin resistanceMaya Matsushita, Motoharu Awazawa, Naoki Kobayashi, Yoshiko M Ikushima, Kotaro Soeda, Miwa Tamura-Nakano, Masafumi Muratani, Kenta Kobayashi, Matthias Blüher, Jens C. Brüning, Kohjiro Ueki
• The effects of caloric restriction on adipose tissue and metabolic health are sex- and age-dependentKarla J Suchacki, Benjamin J Thomas, Yoshiko M Ikushima, Kuan-Chan Chen, Claire Fyfe, Adriana AS Tavares, Richard J Sulston, Andrea Lovdel, Holly J Woodward, Xuan Han, Domenico Mattiucci, Eleanor J Brain, Carlos J Alcaide-Corral, Hiroshi Kobayashi, Gillian A Gray, Phillip D Whitfield, Roland H Stimson, Nicholas M Morton, Alexandra M Johnstone, William P Cawthorn
• Enhanced Angpt1/Tie2 signaling affects the differentiation and long-term repopulation ability of hematopoietic stem cellsYoshiko M Ikushima, Fumio Arai, Yuka Nakamura, Kentaro Hosokawa, Yoshiaki Kubota, Masanori Hirashima, Hirofumi Toyama, Toshio Suda

• ニッチによるがん幹細胞制御機構の解析須田 年生, 田久保 圭誉, 永松 剛, 生島 芳子
• 単一細胞レベルでの造血幹細胞の対称・非対称分裂の制御機構の解明松元 芳子
• 膵β細胞の量・機能を制御する細胞内シグナルの同定生島 芳子
• Biomimetic環境での造血幹細胞の分裂様式解析と培養条件の最適化について生島 芳子, 新井 文用, 細川 健太郎, 須田 年生

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