東京科学大学 · 医歯学総合研究科 · 助教

研究关键词nonalcoholic steatohepatitis・nonalcoholic fatty liver disease・SGLT2 inhibitors・adipose tissue fibrosis・macrophage polarization・hepatocellular carcinoma・metabolic inflammation

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• Masato Horino, Kenji Ikeda, Rei Okazaki, Yujiro Nakano, Ryo Kaneda, Ryoko Ishii, Jun Aoki, Kazunari Hara, Akira Takeuchi, Yoshihiro Niitsu, Kuniyuki Taguchi, Kuniyuki Kano, Masanori Murakami, Kazutaka Tsujimoto, Chikara Komiya, Tetsuya Yamada. Car4-positive adipocyte progenitor cells adapt to the aging environment and work as protection against ROS via glutathione metabolism. Sci Rep. 2025.08; 15 (1): 31922. ( PubMed , DOI )2025
• Daisuke Koga, Ryo Kaneda, Chikara Komiya, Satoshi Ohno, Akira Takeuchi, Kazunari Hara, Masato Horino, Jun Aoki, Rei Okazaki, Ryoko Ishii, Masanori Murakami, Kazutaka Tsujimoto, Kenji Ikeda, Hideki Katagiri, Hideyuki Shimizu, Tetsuya Yamada. Artificial intelligence identifies individuals with prediabetes using single-lead electrocardiograms. Cardiovasc Diabetol. 2025.11; 24 (1): 415. ( PubMed , DOI )2025
• Hara K, Murakami M, Shiba K, Tsujimoto K, Komiya C, Ikeda K, Yamamoto K, Taguchi T, Akashi T, Yoshida S, Ohashi K, Fujii Y, Yamada T.. Unexpected Remission of Bilateral Hyperaldosteronism After Unilateral Cortisol-Producing Adenoma Resection: A Report of Two Cases. Case Rep Endocrinol.. 2025.06; 9941688 ( PubMed )2025
• Akira Takeuchi, Kazutaka Tsujimoto, Jun Aoki, Kenji Ikeda, Nozomu Kono, Kuniyuki Kano, Yoshihiro Niitsu, Masato Horino, Kazunari Hara, Rei Okazaki, Ryo Kaneda, Masanori Murakami, Kumiko Shiba, Chikara Komiya, Junken Aoki, Tetsuya Yamada. Sex difference in BAT thermogenesis depends on PGC-1α-mediated phospholipid synthesis in mice. Nat Commun. 2025.07; 16 (1): 6072. ( PubMed , DOI )2025

• 脂肪組織に由来するエクソソームmiRNAを介した肝細胞増殖機構の解明
• 生活習慣病における慢性炎症の病態生理学的意義に関する研究
• 非アルコール性脂肪肝炎におけるエクソソームを介した脂肪組織－肝臓連関機構の解明

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