東京科学大学 · 医歯学総合研究科 · 助教

研究关键词AQP2 regulation・nephrogenic diabetes insipidus・vasopressin signaling・renal tubular physiology・chronic kidney disease・kidney endocrinology・oxidative stress response・mineralocorticoid signaling

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• Ando F, Hara Y, Uchida S. Identification of protein kinase A signalling molecules in renal collecting ducts. The Journal of physiology. 2024.06; ( PubMed , DOI )2024
• Kurimoto Junki, Takagi Hiroshi, Miyata Takashi, Kawaguchi Yohei, Hodai Yuichi, Tsumura Tetsuro, Hagiwara Daisuke, Kobayashi Tomoko, Yasuda Yoshinori, Sugiyama Mariko, Onoue Takeshi, Iwama Shintaro, Suga Hidetaka, Banno Ryoichi, Katsuki Takeshi, Ando Fumiaki, Uchida Shinichi, Arima Hiroshi. Mineralocorticoids induce polyuria by reducing apical aquaporin-2 expression of the kidney in partial vasopressin deficiency ENDOCRINE JOURNAL. 2023; 70 (3): 295-304.2023
• Suzuki S, Ando F, Kitagawa S, Hara Y, Fujiki T, Mandai S, Susa K, Mori T, Sohara E, Rai T, Uchida S. ZNF185 prevents stress fiber formation through the inhibition of RhoA in endothelial cells. Communications biology. 2023.01; 6 (1): 29. ( PubMed , DOI )2023
• Yanagawa H, Hara Y, Ando F, Suzuki S, Fujiki T, Oikawa D, Yui N, Mandai S, Mori Y, Susa K, Mori T, Sohara E, Tokunaga F, Uchida S. LRBA signalosomes activate vasopressin-induced AQP2 trafficking at recycling endosomes. The Journal of physiology. 2023.12; 601 (23): 5437-5451. ( PubMed , DOI )2023

• 新規PKA活性制御法による肥満症治療法の開発
• 新規PKA活性制御法による肥満症治療法の開発
• LRBAを基軸とした新たな疾患概念の確立と治療法の開発
• 細胞内シグナル伝達分子の活性化が髄質内層集合管の水・尿素透過性に及ぼす影響の検討

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