東京科学大学 · 医歯学総合研究科 · 講師

研究关键词blastocyst complementation・interspecies organogenesis・human pluripotent stem cells・intercellular mRNA transfer・skin organogenesis・parathyroid gland regeneration・thymus complementation・primordial germ cell-like cells

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• Shihan Zeng, Ayaka Yanagida, Noriaki Ota, Mami Uemura, Yoshikazu Hirate, Ryuji Hiramatsu, Naoaki Mizuno, Yoshiakira Kanai, Masami Kanai-Azuma. Identification of Gallbladder-Specific Distal Regulatory Sequence of Murine Sox17. Genes Cells. 2025.01; 30 (1): e13186. ( PubMed , DOI )2025
• Yosuke Yoneyama, Ran-Ran Zhang, Mari Maezawa, Hideki Masaki, Masaki Kimura, Yuqi Cai, Mike Adam, Sreeja Parameswaran, Naoaki Mizuno, Joydeep Bhadury, So Maezawa, Hiroshi Ochiai, Hiromitsu Nakauchi, S Steven Potter, Matthew T Weirauch, Takanori Takebe. Intercellular mRNA transfer alters the human pluripotent stem cell state. Proc Natl Acad Sci U S A. 2025.01; 122 (4): e2413351122. ( PubMed , DOI )2025
• Masaki Nagaya, Ayuko Uchikura, Kazuaki Nakano, Masahito Watanabe, Hitomi Matsunari, Kazuhiro Umeyama, Naoaki Mizuno, Toshiya Nishimura, Hiromitsu Nakauchi, Hiroshi Nagashima. Generation of insulin-like growth factor 1 receptor-knockout pigs as a potential system for interspecies organogenesis. Regen Ther. 2024.06; 26 783-791. ( PubMed , DOI )2024
• Hisato Nagano, Naoaki Mizuno, Hideyuki Sato, Eiji Mizutani, Ayaka Yanagida, Mayuko Kano, Mariko Kasai, Hiromi Yamamoto, Motoo Watanabe, Fabian Suchy, Hideki Masaki, Hiromitsu Nakauchi. Skin graft with dermis and appendages generated in vivo by cell competition. Nature Communications. 2024.04; 15 (1): 3366. ( PubMed , DOI )2024

• ヒト多能性幹細胞由来ブラストイド を用いた、試験管内ヒト着床後胚発生モデルの構築
• 染色体移植によるヒトトリソミーモデルマウスの開発
• 新規カニクイザル発生工学技術を用いた栄養膜特異的ノックアウト法の開発
• 造血幹細胞体外増幅系を用いた幹細胞性・加齢・発癌機構の解析

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