東京科学大学 · 総合研究院 · 准教授

研究关键词protein crystallography・neutron crystallography・antibody affinity maturation・peptide bond planarity・PDZ domain conformational diversity・chloride transporter SLC26A9・green fluorescent protein・iron-sulfur proteins

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• Yoshida M, Hanazono Y, Numoto N, Yabuno S, Ito N, Azuma T, Oda M. Structural basis of affinity maturation of anti-(4-hydroxy-3-nitrophenyl)acetyl antibodies. Archives of biochemistry and biophysics. 2026.01; 775 110665. ( PubMed , DOI )2026
• Ando N, Hanazono Y, Sakuma K, Numoto N, Hamajima R, Tenno T, Oshima A, Ito N, Hiroaki H. Intrinsically dominant conformational diversity in PDZ1 within the tandem PDZ1-PDZ2 of human syntenin-1 underlined by crystal structures. Protein science : a publication of the Protein Society. 2026.06; 35 (6): e70607. ( PubMed , DOI )2026
• Mudiyanselage HNTN, Misawa T, Ochiai K, Demizu Y, Hanazono Y, Ito N, Fujii S. Design, synthesis and structural development of nonsecosteroidal VDR ligands based on the C,C'-diphenyl-m-carborane scaffold. European journal of medicinal chemistry. 2026.01; 302 (Pt 2): 118320. ( PubMed , DOI )2026
• Nishina, S; Kofuji, S; Matsubara, K; Anzai, H; Hirakata, K; Hanazono, Y; Okamoto-Uchida, Y; Hirayama, J; Ito, N; Fukami, M; Nishina, H. A novel OPHN1 variant associated with cyclic strabismus but in the absence of OPHN1 syndrome SCIENTIFIC REPORTS. 2026.04; 16 (1): ( PubMed , DOI )2026

• 電子状態から読み解く鉄硫黄タンパク質の酸化還元反応
• 高分解能X線および中性子線回折による高電位鉄硫黄タンパク質の酸化還元反応の理解

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